University of Cologne

CECAD Cluster of Excellence
CECAD Research Center

Joseph-Stelzmann-Str. 26
50931 Cologne

Tel.: 0049(0)221478 - 84216
Tel.: 0049(0)221478 - 84210
Fax.: 0049(0)221478 - 84217

Public record at ORCID





Kumsta C., Chang J.T., Lee R., Tan E.P., Yang Y., Loureiro R., Choy E.H., Lim S. H.Y., Saez I., Springhorn A., Hoppe T., Vilchez D., Hansen M. (2019). The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy. Nat Commun. 10: 5648.


Ottens F., Finger F., and Hoppe T. (2019). Wie der Geruch von Nahrung Stoffwechsel und Altern beeinflusst. Nutrition News 3, 3-5.


Bakula D., Ablasser A., Aguzzi A., Antebi A., Barzilai N., Bittner M.I., Jensen M.B., Calkhoven C.F., Chen D., Grey A.D.N.J., Feige J.N., Georgievskaya A., Gladyshev V.N., Golato T., Gudkov A.V., Hoppe T., Kaeberlein M., Katajisto P., Kennedy B.K., Lal U., Martin-Villalba A., Moskalev A.A., Ozerov I., Petr M.A., Reason, Rubinsztein D.C., Tyshkovskiy A., Vanhaelen Q., Zhavoronkov A., Scheibye-Knudsen M. (2019). Latest advances in aging research and drug discovery. Aging 2019 Nov 21;11(22):9971-9981


Herzog L.K., Kevei É., Marchante R., Böttcher C., Bindesbøll C., Lystad A.H., Pfeiffer A., Gierisch M.E., Salomons F.A., Simonsen A., Hoppe T.*, Dantuma N.P. (2019). The Machado–Joseph disease deubiquitylase ataxin‐3 interacts with LC3C/GABARAP and promotes autophagy. Aging Cell 2019 Oct 17:e13051. doi: 10.1111/acel.13051. [Epub ahead of print] (*co-corresponding author)


Finger F., Ottens F., Springhorn A., Drexel T., Proksch L., Metz S., Cochella L., Hoppe T. (2019). Olfaction regulates organismal proteostasis and longevity via miRNA-dependent signaling. Nature Metabolism 1, 350–59.


Springhorn A. and Hoppe T. (2019). Western blot analysis of the autophagosomal membrane protein LGG-1/LC3 in Caenorhabditis elegans. Method Enzymol. 619, 319-36.




Koyuncu S., Saez I., Lee H.J., Gutierrez-Garcia R., Pokrzywa W., Fatima A., Hoppe T., Vilchez D. (2018). The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients. Nat Commun. 9: 2886.


Franz A. and Hoppe T. (2018). Stressed out: mitohormesis is crossing borders. Trends Endocrinol Metab. 29, 525-527.


Höhfeld J. and Hoppe T. (2018). Ub and down: ubiquitin exercise for the elderly. Trends Cell Biol. 28, 512-522.


Dreher L.S., Hoppe T. (2018). ERADicate tumor progression with metformin. Mol Cell. 71, 481-482.


Dreher L.S., Hoppe T. (2018). Hepatic ERAD takes control of the organism. EMBO J. .


Balaji V., Pokrzywa W., and Hoppe T. (2018). Ubiquitylation pathways In insulin signaling and organismal homeostasis. Bioessays. 40: e1700223.




Tawo R., Pokrzywa W., Kevei E., Akyuz M.E., Balaji V., Arian S., Höhfeld J., Hoppe T. (2017). The Ubiquitin ligase CHIP integrates proteostasis and aging by regulation of insulin receptor turnover. Cell 169, 470-82.


Schulz J., Avci D., Queisser M.A., Gutschmidt A., Dreher L.S., Fenech E.J., Volkmar N., Hayashi Y., Hoppe T., Christianson J.C. (2017). Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD). J Cell Sci. 130, 3322-35


Pokrzywa W. and Hoppe T. (2017). CHIPped balance of proteostasis and longevity. Oncotarget. 8, 96472-3.


Pokrzywa W., Lorenz R., Hoppe T. (2017). Chaperone-directed ubiquitylation maintains proteostasis at the expense of longevity. Worm 6, e1371403.


Kevei É., Pokrzywa W., Hoppe T. (2017). Repair or destruction-an intimate liaison between ubiquitin ligases and molecular chaperones in proteostasis. FEBS Lett. 591, 2616-35.




Ackermann L., Schell M., Pokrzywa W., Kevei E., Gartner B., Schumacher B., Hoppe T. (2016). E4 ubiquitin ligase specific degradation hubs coordinate DNA double strands break repair. Nat Struct Mol Biol. 23,995-1002.


Liebl M.P., Hoppe T. (2016). It's all about talking: two-way communication between proteasomal and lysosomal degradation pathways via ubiquitin. Am J Physiol Cell Physiol. 311(2):C166-78.


Franz A., Ackermann L. and Hoppe T. (2016). Ring of change: CDC48/p97 drives protein dynamics at chromatin. Front. Genet. 7:73.


Klionsky D.J. et al., (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12, 1-222.


Franz A., Pirson P.A., Pilger D., Halder S., Achuthankutty D., Kashkar H., Ramadan K., Hoppe T. (2016). Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression. Nat Commun. 7:10612.




Franz A., Kevei É., Hoppe T. (2015). Double-edged alliance: mitochondrial surveillance by the UPS and autophagy. Curr Opin Cell Biol. 37, 18-27.


Brinkmann K., Schell M., Hoppe T. and Kashkar H. (2015) Regulation of the DNA damage response by ubiquitin conjugation. Front. Genet. 6:98.




Bonizec M., Herissant L., Pokrzywa W., Geng F., Wenzel S., Howard G.C., Rodriguez P., Krause S., Tansey W.P., Hoppe T., Dargemont C. (2015). The ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B. Nucleic Acids Res. 42, 10975-86.


Frumkin A., Dror S., Pokrzywa W., Bar-Lavan Y., Karady I., Hoppe T., Ben-Zvi A. (2014). Challenging muscle homeostasis uncovers novel chaperone interactions in Caenorhabditis elegans. Front. Mol. Bio. 1:21.


Segref A., Kevei E., Pokrzywa W., Schmeisser K., Mansfeld J., Livnat-Levanon N., Ensenauer R., Glickman M.H., Ristow M., Hoppe T. (2014). Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system. Cell Metab. 19, 642-52.


Denzel M.S., Storm N.J., Gutschmidt A., Baddi R., Hinze Y., Jarosch E., Sommer T., Hoppe T., Antebi A. (2014). Hexosamine pathway metabolites enhance protein quality control and prolong life. Cell 156, 1167-78.


Livnat-Levanon N., Kevei E., Kleifeld O., Krutauz D., Segref A., Rinaldi T., Erpapazoglou Z., Cohen M., Reis N., Hoppe T., Glickman M.H. (2014). Reversible 26S Proteasome disassembly upon mitochondrial stress. Cell Rep. 7, 1371-80.


Hou N.S., Gutschmidt A., Choi D.Y., Pather K., Shi X., Watts J.L., Hoppe T., Taubert S. (2014). Activation of the ER unfolded protein response by lipid disequilibrium without disturbed proteostasis in vivo. Proc. Natl. Acad. Sci. 111, E2271-80.


Franz A., Ackermann L., Hoppe T. (2014). Create and preserve: proteostasis in development and aging is governed by Cdc48/p97/VCP. Biochim Biophys Acta. 1843, 205-15.


Kevei E. and Hoppe T. (2014). Ubiquitin sets the timer: impacts on aging and longevity. Nat Struct Mol Biol. 21, 290-2.


Hoppe T.  (2014). Limited Proteolysis: DisRUPting Proteasomal Inhibition.
Curr Biol. 24, R693-5.


Finger F. and Hoppe T. (2014). MicroRNAs meet calcium: Joint venture in ER proteostasis. Sci. Signal. 7, re11.



Gazda L., Pokrzywa W., Hellerschmied D., Löwe T., Forné I., Mueller-Planitz F., Hoppe T.*, Clausen T. (2013). The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans. Cell 152, 183-95. (*co-corresponding author)


Ermolaeva M.A., Segref A., Dakhovnik A., Ou H.L., Schneider J.I., Utermöhlen O., Hoppe T., Schumacher B. (2013). DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance. Nature 501, 416-20.


Schipanski A., Lange S., Segref A., Gutschmidt A., Lomas D.A., Miranda E., Schweizer M., Hoppe T.*, Glatzel M. (2013). A novel interaction between aging and ER overload in a protein conformational dementia. Genetics 193, 865-76. (*co-corresponding author)


Brinkmann K., Zigrino P., Witt A., Schell M., Ackermann L., Broxtermann P., Schüll S., Andree M., Coutelle O., Yazdanpanah B., Seeger J.M., Klubertz D., Drebber U., Hacker U.T., Krönke M., Mauch C., Hoppe T., Kashkar H. (2013). Ubiquitin C-terminal hydrolase-L1 potentiates cancer chemosensitivity by stabilizing NOXA. Cell Rep. 3, 881-91.


Schmeisser K., Mansfeld J., Kuhlow D., Weimer S., Priebe S., Heiland I., Birringer M., Groth M., Segref A., Kanfi Y., Price N.L., Schmeisser S., Schuster S., Pfeiffer A.F., Guthke R., Platzer M., Hoppe T., Cohen H.Y., Zarse K., Sinclair D.A., Ristow M. (2013). Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. Nat Chem Biol. 9, 693-700.


Pokrzywa W., Hoppe T. (2013). Chaperoning myosin assembly in muscle formation and aging. Worm. 2, e25644.



Dantuma N.P. and Hoppe T. (2012). Growing Sphere of Influence: Cdc48/p97 Orchestrates Ubiquitin-Dependent Extraction from Chromatin. Trends Cell Biol. 22, 483-91.


Basel-Vanagaite L., Dallapiccola B., Ramirez-Solis R., Segref A., Hoppe T., Kubisch C., Adams D.J., Borck G. (2012). Deficiency for the ubiquitin ligase UBE3B in an intellectual disability syndrome. Am J Hum Genet. 91, 998-1010.


Segref A. and Hoppe T. (2012). Analysis of ubiquitin-dependent proteolysis in C. elegans. Methods Mol Biol. 832, 531-44.



Kuhlbrodt K., Janiesch P.C., Kevei E., Segref A., Barikbin R., and Hoppe T. (2011). The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis. Nat. Cell Biol. 13, 273-81.


Franz A., Orth M., Pirson P.A., Sonneville R., Blow J.J., Gartner A., Stemmann O., Hoppe T. (2011). CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication. Mol Cell. 44, 85-96.


Acs K., Luijsterburg M.S., Ackermann L., Salomons F.A., Hoppe T. Dantuma N.P. (2011). The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks. Nat Struct Mol Biol. 18, 1345-50.


Segref A, Torres S, Hoppe T. (2011). A Screenable in vivo Assay to Study Proteostasis Networks in Caenorhabditis elegans. Genetics. 187, 1235-40.



Hoppe T. (2010). Life and destruction: ubiquitin-mediated proteolysis in aging and longevity. F1000 Biol Rep 2: 79


Segref A. and Hoppe T. (2009). Think locally: control of ubiquitin-dependent protein degradation in neurons. EMBO reports 10, 44-50.


Deichsel A., Mouysset J., and Hoppe T. (2009). The ubiquitin-selective chaperone CDC-48/p97, a new player in DNA replication. Cell Cycle 8, 1-6.


Hoppe T. (2009). Less is more: how protein degradation regulates muscle development. Ernst Schering Found Symp Proc. 1, 67-73.



Mouysset J., Deichsel A., Moser S., Hoege C., Hyman A.A., Gartner A., and Hoppe T. (2008). Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication. Proc. Natl. Acad. Sci. 105, 12879-84.


Kim J., Löwe T., and Hoppe T. (2008). Protein quality control gets muscle into shape. Trends Cell Biol. 18, 264-72.



Janiesch P.C., Kim J., Mouysset J., Barikbin R., Lochmüller H., Cassata G., Krause S., and Hoppe T.  (2007). The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy. Nat. Cell Biol. 9, 379-90.


Landsverk M.L., Hutagalung A.H., Li S., Najafov A., Hoppe T., Barral J.M., and Epstein H.F. (2007). The UNC-45 Chaperone Mediates Sarcomere Assembly through Myosin Degradation in C. elegans. J. Cell Biol. 177, 205-10.



Mouysset J., Kähler C., and Hoppe T. (2006). A Conserved Role of C. elegans CDC-48 in ER-Associated Protein Degradation. J. Struct. Biol. 156, 41-49.


Kim J., and Hoppe T. (2006). The ubiquitin/proteasome system and muscle development. Protein Degradation 3, published by WILEY-VCH, 21-39.



Hoppe T. (2005). Multiubiquitylation by E4 enzymes: one size doesn't fit all. Trends Biochem. Sci. 30, 183-187.


Kuhlbrodt K., Mouysset J., and Hoppe T. (2005). Orchestra for assembly and fate of multiubiquitin chains. Essays Biochem. 41, 1-14.


Springer W., Hoppe T., Schmidt E., and Baumeister R. (2005). A Caenorhabditis elegans Parkin mutant with altered solubility couples α-synuclein aggregation to proteotoxic stress. Hum. Mol. Genet. 14, 3407-23.



Hoppe T., Cassata G., Barral J.M., Springer W., Hutagalung A.H., Epstein H.F., and Baumeister R. (2004). Regulation of the Myosin-Directed Chaperone UNC-45 by a Novel E3/E4-Multiubiquitylation Complex in C. elegans. Cell 118, 337-49.


Hertweck M., Hoppe T., and Baumeister R. (2003). C. elegans, a model for aging with high-throughput capacity. Exp. Gerontol. 38, 345-346.


Rape M., Hoppe T., Gorr I., Kalocay M., Richly H., and Jentsch S. (2001). Mobilization of Processed, Membrane-Tethered SPT23 Transcription Factor by CDC48UFD1/NPL4, a Ubiquitin-Selective Chaperone. Cell 107, 667-677.


Hoppe T., Rape M., and Jentsch S. (2001). Membrane-bound transcription factors: regulated release by RIP or RUP. Curr. Opin. Cell Biol. 13, 344-348.


Hoppe T., Matuschewski K., Rape M., Schlenker S., Ulrich H.D., and Jentsch S. (2000). Activation of a Membrane-Bound Transcription Factor by Regulated Ubiquitin/Proteasome-Dependent Processing. Cell 102, 577-586. 


Koegl M., Hoppe T., Schlenker S., Ulrich H.D., Mayer T.U., and Jentsch S. (1999). A Novel Ubiquitination Factor, E4, Is Involved in Multiubiquitin Chain Assembly. Cell 96, 635-644.




Cologne Seminars on Ageing >>more..

Next Journal Club on March 5 at 9 am >>more..

Next Progress Report on March 2 at 10 am >>more..

Welcome to our new Guest Scientist >>more..

Welcome to our new PhD Student >>more..

Spring Meeting 2020: 3rd Cologne Aging Conference >>more..

New Paper out in Aging Cell >>more..